A Post-doctoral position is immediately available in the area of ubiquitin signaling, focusing on brain function and neurodegenerative disease in the Dr. Subramaniam laboratory at The Scripps Research Institute (TSRI), Florida, USA. http://www.scripps.edu/subramaniam/index.html
A candidate with a Ph.D. and strong interest in dissecting the signaling pathways, using biochemical, genetic, and animal models is encouraged to apply. Aspiring candidate must have a deep knowledge of signaling pathways, previous experience in addressing the mechanisms supported by a publication record. A postdoctoral candidate looking for an opportunity to explore and contribute to neuroscience research is particularly encouraged to apply. Experience in small-ubiquitin-like modifiers (SUMO) signaling is a plus.
The Scripps-Florida, Neuroscience department, provides state-of-the-art facilities for research. A successful candidate will experience a high-class intellectual and collaborative atmosphere enriched with excellent faculty and multi-disciplinary research, both within Scripps-Florida and surrounding Max Planck Neuroscience and Florida Atlantic University Brain Institutes.
Please see below the selected publications for research details:
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Shahani N, Huang WC, Varnum M, Page DT, Subramaniam S. Neurobiol Aging. 2016 Nov 21;50:134-143.
RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S. Sci Signal. 2016 Nov 15;9(454):ra111.
Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Swarnkar S, Chen Y, Pryor WM, Shahani N, Page DT, Subramaniam S. Neurobiol Dis. 2015 Oct;82:66-77.
Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.
Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S.
Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00027-3.
Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.
Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S.
Sci Signal. 2014 Oct 28;7(349):ra103.