An outstanding, highly-motivated post-doctoral fellow is sought to participate in studies on the cellular/network mechanisms of cortical network function.
We are investigating the mechanisms by which the optimal state for detection and discrimination performance is achieved in mouse neocortex. Mice are trained to perform visual and auditory detection/recognition/discrimination tasks. Through state-of-the-art techniques, such as two-photon monitoring of activity in known neuromodulatory axons in the cortex, whole cell recording of synaptic activity, high density array recordings of cortical unit activity, and optogenetic manipulation of specific transmitter systems, we are able to determine and decipher the role of different transmitter systems and neural pathways that rapidly control neuronal responsiveness. We have recently shown that the waking state varies on a continual basis and that these fluctuations account for a large component of response and behavioral variance. We take a circuit-based approach to systems neuroscience, revealing how the nervous system achieves a goal through the synaptic interaction of cells in local and long range circuits, modulated by neurotransmitters, to generate flexible behavior.
In summer 2017 our laboratory is moving to the Institute of Neuroscience at the University of Oregon in anticipation of the building of the Knight Science campus, funded by a historic gift from Phil Knight of Nike. You will be joining an exciting scientific atmosphere that offers amazing work/life balance.
Support: Postdoctoral fellows are well supported with state-of-the-art equipment dedicated to their experiments. Salary is competitive and commensurate with experience and contribution.