We are seeking to recruit as soon as possible a post-doctoral fellow expert in slice electrophysiology and imaging to study AMPA receptor trafficking and synaptic function with innovative molecular and imaging approaches.
The project aims at studying the molecular and mechanistic basis of synaptic plasticity in hippocampal brain slices and in vivo.
Building on the past work of the Choquet group demonstrating the key role of AMPA receptor surface trafficking in synaptic function, we have devised a variety of innovative molecular tools to control with a high spatio-temporal resolution various aspects of AMPA receptor traffic. In this project, we will use these optogenetic tools to analyse the specific role of various AMPA receptor trafficking pathways in short and long term synaptic plasticity, both in hippocampal brain slices and in vivo. We will also use high end imaging approaches to image AMPA receptor traffic in brain slices with unprecedented precision and resolution.
Altogether, this project will shine new light on the molecular mechanism of synaptic plasticity and will be linked to behavioural studies of cognitive functions using the same tools.
The position will be financed by an ERC grant from D. Choquet for 24 months.
For this position, we are seeking highly motivated individuals, with a proven track record of success, if possible immediately after their PhD, and in any case no more than four years after their PhD. The projects will be conducted in a stimulating and highly interdisciplinary and international environment in a newly established research building, a part of the Bordeaux neurocampus project (Bordeaux, France).
The team develops several research topics, combining neuroscience, physics and chemistry in order to unravel the dynamics of multimolecular complexes and their role in synaptic transmission.
We have a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components of glutamatergic synapses and synaptic transmission. Our projects build on our rec...ent findings that:
trafficking of neuronal molecules such as glutamate receptors is highly dynamic,
regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis,
modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity.
By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, we will develop 3 main research axes:
dynamics and physical-chemistry of the macro-molecular complexes of the synapse,
nano-scale organization and dynamics of synaptic proteins and membrane trafficking,
impact of the dynamic of synapse organization on synaptic physiology.
Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function.