The Thathiah laboratory in the Department of Neurobiology at the University of Pittsburgh School of Medicine is looking for a highly motivated postdoctoral fellow who is passionate about neuroscience and disease-related research to study the molecular and cellular mechanisms underlying the pathophysiology of Alzheimer’s Disease (AD). The position is ideal for a person who is interested in understanding the relationship between the accumulation of DNA damage, DNA repair mechanisms, and neurodegeneration in AD.
Oxidative stress is regarded as one of the earliest pathological changes in AD. Neurons in the brain are particularly vulnerable to oxidative stress and the accumulation of DNA damage. The aim of this research is to investigate DNA repair mechanisms in postmitotic neurons in response to DNA damage with the goal of developing effective strategies to prevent or slow the progression of age-related neurodegeneration and neurodegenerative diseases. We use a multidisciplinary approach, combining genetically engineered mouse models with molecular, cellular and biochemical techniques to study potential disease-causing factors and pathways involved in AD. We believe that basic scientific discovery will steer the course toward the effective treatment and prevention of AD.
A recent Ph.D. in neuroscience, biology, biochemistry or related field and proficiency in molecular and biochemical approaches is required. Prior experience in a relevant research area, e.g. DNA damage signaling and repair, is preferred. Experience with cell and neuronal cultures is preferred. Experience with mouse handling, including injection, dissection, and behavioral approaches is preferred. Excellent verbal and written communication skills, technical expertise, and scientific creativity are essential.
Interested postdoctoral candidates should send a brief statement of research accomplishments and future interests and the contact information for three references to:
The University of Pittsburgh has a long history of research accomplishments and excellence in neuroscience. The Pittsburgh Brain Institute is a University initiative whose central mission is to unlock the mysteries of normal and abnormal brain function and to translate the discoveries which result from this effort into novel approaches to overcome brain disorders. This is a new institute (Peter L. Strick, Scientific Director) within the University’s large neuroscience communities, spanning the Schools of Medicine, Arts & Sciences, and Engineering.