Postdoctoral Positions at The Miami Project To Cure Paralysis
The Miami Project to Cure Paralysis
January 3, 2018
Starting at 47484.00
Full Time - Entry Level
Academic / Research
Two postdoctoral positions are available at The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami.
The first position (MO-01) is for a VHA-funded project that involves electrophysiological studies in rats with spinal cord injury (SCI) in the laboratory of Dr. Martin Oudega. The data generated in this project will be validated in humans with SCI in the laboratory of Dr. Monica Perez. This project aims to develop new clinical approaches to enhance synaptic strength between residual corticospinal tract axons and spinal motoneurons using spike timing-dependent plasticity (STDP) protocols to improve upper-limb function in humans with incomplete cervical SCI. The specific goals are to: 1) develop methodologies to maximize STDP-induced aftereffects in an adult rat model of incomplete SCI and 2) translate this knowledge to humans to maximize STDP-mediated motor function recovery after incomplete cervical SCI.
The second position (MO-02) is for a NIH-funded project that investigates mechanisms underlying intermingling of transplanted Schwann cells with host spinal cord astrocytes after treatment with the anti-metabolite, 6-aminonicotinamide. Data from in vitro studies will be used to develop approaches to create interfaces between Schwann cell transplants and the spinal cord that are more conducive for axon growth in an adult rat model of contusive SCI. These studies will be conducted in the laboratory of Dr. Martin Oudega.
For MO-01: Experience in intracortical microsimulation will be a plus. The post-doctoral candidate will gain expertise in different spinal cord injury models, tracing of descending tracts and motoneurons, pharmacological agents, quantification of synaptic density, assessment of functional recovery, etc.
Fore MO-02: Experience in cell culture techniques will be a plus. The post-doctoral candidate will gain expertise in Schwann cell and astrocyte biology, cell culture technique, viral vector biology, adult rat spinal cord injury models, immunocytochemistry, tracing axon pathways, assessment of functional recovery, etc.
The Miami Project is a Center of Excellence at the University of Miami Miller School of Medicine. It is considered the premier investigative research program conducting cutting edge discovery, translational, and clinical investigations targeting spinal cord and brain injuries. Since its inception, research at The Miami Project has changed the landscape of knowledge and therapeutic strategies for spinal cord and traumatic brain injury.