Two Positions Available in the Russek Laboratory for Translational Epilepsy
The research in the Russek Laboratory is aimed at understanding the relationship of the expressed and repressed genome to multiple brain disorders where inhibitory processes are dysregulated (Temporal Lobe Epilepsy, Autism Spectrum Disorder, and Alzheimer’s Disease) and where seizures, cognitive impairment, and anxiety are comorbidities. Multiple collaborations are aimed at discovering the transcriptome and epigenome that specify the cell specific activities of neural networks and associated disruption in behavior to develop a strategic window for discovery science and drug therapy. Major approaches used in the lab at this time include RNA-sequencing and ChIP-sequencing as well as proteomics. Current opportunities to contribute to translational as well as basic science research are: Research Assistant (Post-Bac) and Research Associate (Post-PhD).
Post-Bac: Prior research experience using molecular biological techniques is required with either terminal undergraduate or masters level study. Some familiarity with RNA-sequencing and/or ChIP-sequencing is preferred but not required.
Postdoctoral: Prior thesis research experience using advanced molecular biological techniques for open discovery science is required.
Additional Salary Information: Dependent on the level of relevant research experience.
The Laboratory for Translational Epilepsy is lead by Professor Shelley J. Russek who is also the director of the university-wide Neuroscience PhD program at Boston University. The goal of the lab is to develop new therapeutic strategies for the treatment of brain disorders using transcriptomic and genomic/epigenomic techniques to identify common mechanisms of disease etiology (epilepsy, autism and... dementia). Collaborative projects are ongoing to link the dysregulated activity of neural circuits and their associated behavioral disturbance to cell specific alterations in the transcriptome of transgenic mice and rats.