A postdoctoral position to study neuroinflammation in mouse models of retinal degeneration are available in the laboratory of Marie Burns, PhD at the University of California, Davis. The Burns Lab studies photoreceptor physiology, pathophysiology, and the immune response to photoreceptor degeneration. The retina is an ideal model system because it is a well-defined circuit of known structure and function, is readily amenable to biochemical perturbations and quantitative flow cytometric methods, and sits behind a naturally transparent optical system that facilitates non-invasive in vivo imaging of individual cells. The goal of the project is to understand microglial cells in healthy and degenerating retina and to differentiate their function from those of infiltrating monocytes as disease progresses using mouse models. Techniques include in vivo OCT/adaptive optics-SLO imaging to observe microglial and monocyte dynamics in vivo, as well as flow cytometry, scRNAseq, ELISAs, and novel pharmacological approaches addressing molecular signaling pathways underlying microglial activation and migration.
The ideal candidate will have a strong background in in vivo imaging, cellular neuroscience and/or the innate immune system, and show clear scientific enthusiasm and strong work ethic. UC Davis offers a highly collaborative research environment and excellent opportunities for training and career development, including NIH-funded training programs associated with the UC Davis Center for Visual Sciences and the Center for Neuroscience. The successful candidate will have access to a highly collaborative group of neuroscientists and medical physicists focused on the development of novel imaging technologies and multi-disciplinary approaches to understand and mitigate neurodegeneration.
- PhD in Neuroscience, Immunology, Physiology, Pharmacology, or related field.
- A minimum of two first author papers published or accepted in a peer-reviewed journal
- A firm background in basic molecular biology, biochemistry, cell biology, rodent models
- Ability to work both collaboratively and independently, with excellent written and oral English communication skills
Interested applicants should upload a pdf containing CV, a 1-page statement of research expertise and the reasons for your interest in this position, and names/contact information of three references.
Additional Salary Information: Salary will be commensurate with experience.
The Burns Lab studies neuroinflammation in the retina, particularly in response to photoreceptor degeneration. Techniques include in vivo OCT/AO-SLO imaging, 2-photon ex vivo microscopy, RT-PCR and scRNAseq, flow cytometry, single cell electrophysiological recordings, ERGs, and visually-guided behavior.