Postdoctoral Associate or Biological Scientist positions in the Neurovascular Lab of Dr. Sylvain Doré in the UF-Center for Translational Research in Neurodegenerative Disease. The pre-clinical research involves the study of strokes (IS, ICH, SAD), traumatic brain injury (TBI), vascular dementia, CAA, and AD in a team work environment with state-of-the-art facilities. The laboratory uses AAVs and transgenic mouse models to conduct mechanistic studies on the role of anti-inflammatory (cyclooxygenase-prostaglandin, TLR) and anti-oxidant (Nrf2-heme oxygenase-iron) pathways in neuronal disorders to identify novel and effective neuroprotective therapies.
Enthusiastic applicants must submit electronically a letter of interest describing mouse in vivo experience and short/long term goals, detailed CV, and the names of three senior faculty references with email and phone number. Any questions regarding the application process can be directed to Sylvain Doré PhD, FAHA, Director of Research Programs at email@example.com, UF-COM, Depts of Anesthesiology, Neurology, Psychiatry, Pharmaceutics and Neuroscience. UF is now ranked #9 among the 2018 list of top 10 best public universities. Start date is available now until the positions are filled. While at SFN, I encourage you to call for the personal interview, my cell #: 443-803-1910.
Minimum qualifications are a PhD or MD in neuroscience, surgery, physiology, pharmacology, or a closely related field and experience with advances rodent surgeries, handling, genotyping, and physiology techniques is required. Prior experience in ischemic or hemorrhagic stroke is highly desirable, with first author publications. The candidate should have excellent English oral and written skills, and a personal interview is required.
Additional Salary Information: Starting salary will be commensurate with qualifications. The position is eligible for individual and dependent health care plans that include medical, dental, disability, and life insurance benefits. Gainesville FL is a great college town and most affordable!
The goal of the team effort directed by Sylvain is to discover new effective mechanisms that limit neuronal dysfunction associated with ischemic and hemorrhagic Stroke, Alzheimer disease (AD), Aging, and various other neurological disorders. The overall goal is to slow down the progression of the disease, and ultimately stop it. To do so, the aim is to limit neuron death (apoptosis and necrosis) r...esulting from acute and/or chronic neurodegenerative conditions, re-establish normal cerebral blood flow, limit inflammation, and restore regular cellular functions. Using a variety of in vitro and in vivo preclinical models, several new hypotheses and potential therapies are being investigated and developed:
1. One main objective is focused on understanding the actions of prostaglandin (PG) metabolites generated by the degradation of arachidonic acid by cyclooxygenase enzymes. These enzymes are the rate-limiting steps for the production of PGs, which are key elements in the inflammatory response. The resulting consequences are suggested to play an important role in the loss of normal neuronal functions associated with aging and neurodegenerative disorders.
2. We also intend to understand of the protective role of the heme metabolites in the brain using cellular/molecular techniques and various models of stroke, Alzheimer disease, and aging. New knowledge is gained specifically by investigating the action and the role of activity of the heme oxygenase enzyme and its unique bioactive metabolites, namely, carbon monoxide, iron, biliverdin, and bilirubin.
3. Our lab also provides molecular evidence for the potential therapeutic applications of complementary and alternative medicines. Using cultures of neurons, the lab has observed that pre-treatment with a standardized extract of Ginkgo biloba could alter the presence of specific genes/proteins important in neuronal function. Individual components of the extract are ineffective, supporting the synergistic principals of traditional medicine. Similar experiments and results have been obtained using resveratrol and other polyphenols, which appear to be active ingredients concentrated in red wines, and which has been proposed to explain some of the beneficial effects associated with the so called "French Paradox." These bioactive nutrients could provide resistance against damage induced by free radicals, the toxins which are generated with aging and are the hallmark of many neurodegenerative processes, essentially via the transcriptional factor Nrf2.
Dr. Sylvain Dore, Professor, Anesthesiology, Neurology, Psychiatry, Psychology, Pharmaceutics, and Neuroscience, University of Florida College of Medicine, Gainesville, FL, 32610