Applicants are invited to apply for a Postdoctoral Research position in the Petritsch Research Team at the Brain Tumor Research Center at UCSF. We are seeking a highly motivated individual to join our dynamic research group to define the critical mechanisms of early cell fate decisions in oligodendrocyte precursor cells (OPCs). We are investigating in particular the transcriptional, epigenetic and post-translational regulatory mechanisms of asymmetric cell division and how their deregulation contributes to gliomagenesis. We aim to understand how the tumor microenvironment affect cell fate decision of tumor cells. Vice versa we aim to determine how tumor cell differentiation state affects the tumor environment including the immune system. The postdoctoral fellow will be expected to carry out 2-3 projects which span from basic to preclinical research and addresses these questions.
Applicants should include a concise CV, a minimum of three references, a detailed description of past research including the applicants own contributions to this research. Email the application to firstname.lastname@example.org
The subject line should include: your name, "Petritsch Team Application".Applicants interested in meeting the PI at the SFN meeting in Washington D.C., should contact Dr. Petritsch immediately at email@example.com
UCSF postdocs receive a generous benefit package and additional career support and are represented by the postdoctoral Scholars’ association. UCSF offers on-campus housing and child-care upon availability.
Substantial experience in advanced molecular and cell biology techniques are a must, experience with transgenic mouse models or primary human cell culture is a plus. A strong background in more than one of the following areas is necessary: Epigenetic analyses, genome editing, progenitor or stem cell biology, immune system, brain tumor biology, signal transduction, bioinformatics.
Excellent written and oral presentation skills and a good command of the relevant literature in the field are essential. Candidates should have demonstrated their capabilities by peer-reviewed publications and should be willing to guide and supervise students as well as other lab members. We are looking for an enthusiastic individual with a positive attitude towards challenging projects, and who seeks the opportunity to succeed in a productive environment by using excellent facilities.
Additional Salary Information: UCSF has a very competitive salary package for postdoctoral fellows
The Petritsch Lab uses pharmacological, molecular, and in vivo and ex vivo techniques, to uncover the mechanism for cell fate decisions in oligodendrocyte precursor cells, in the healthy and diseased brain.
Oligodendrocytes arise from oligodendrocyte precursor cells (OPCs) and accomplish myelination in the central nervous system to regulate axonal function. Although OPCs are the most abundant p...roliferative population in the adult and ageing brain, we are only beginning to understand their heterogeneity and the underlying molecular regulation of OPC functions.
Do OPCs in the adult central nervous system decide about their fate that is to proliferate or differentiate, by undergoing asymmetric divisions? Does the underlying mechanism of asymmetric cell divisions in mammalian cells diverge from the conserved process found in Drosophila neuroblasts? Does it involve epigenetic regulators? Is there a cell intrinsic or extrinsic mechanism that determines whether OPC divisions are symmetrical or asymmetrical?
Deviations from the normal OPC fate leads to a number of diseases, such as gliomas, and demyelinating disorders, including multiple sclerosis (MS).
What are the consequences of deregulation of asymmetric OPC division for the central nervous system? Are defective asymmetric divisions the cause for deviation from the normal OPC fate? If so, can we pinpoint the molecules that are crucial for the deregulation of cell fate and characterize them as novel targets for anti-glioma therapy?
We strive for scientific excellence in a well-mentored environment that fosters integrity, collaboration, respect, and originality.