Design, construction, and characterization of optogenetic proteins. This position will primarily focus on constructing light-activated analogs of proteins implicated in the pathways that control medium spiny neuron (MSN) electrophysiology. These studies are designed to correlate MSN biochemical activity with specific organismal behaviors, including addiction and locomotion. The candidate is expected to work in a team environment, contribute to the scientific development of graduate students, present at scientific meetings and prepare manuscripts for publication.
Experience with standard molecular biology techniques (multiple cloning methods), protein expression/characterization, cell culture, and live cell imaging/fluorescence microscopy.
PhD degree in biology, biochemistry, chemical biology or related field is required.
Additional Salary Information: Salary dependent on qualifications and experience
Research in the Division of Chemical Biology and Medicinal Chemistry at the UNC Eshelman School of Pharmacy spans activities in contemporary chemical biology and drug discovery and blends the principles and experimental techniques of chemistry and biology with computational science. While maintaining a traditional emphasis on the drug candidate, we integrate contemporary biological methods to merg...e small molecule and target biomolecule research. This approach allows for elucidation of disease pathways and mechanisms of drug action. Our program encompasses nearly all aspects of drug discovery, including bioactive natural products, organic chemistry, computational drug design, assay development, high throughput screening of chemical libraries, and studies in living cells.
The division works closely with biotech and pharmaceutical companies in North Carolina’s Research Triangle and is a campus-wide leader in new scientific inventions. Discoveries made by CBMC investigators have led to three FDA-approved drugs, two spin-off companies, and several compounds in advanced phases of clinical trials for cancer and infectious diseases.