Research focuses on differential effects of kappa opioid receptor (KOR) agonists on behaviors and investigation of the biochemical mechanisms underlying the differences using techniques including behavioral tests (analgesia, anti-scratch, conditioned place aversion, hypolocomotion and motor incoordination) and biochemical pharmacology approaches (receptor phosphorylation and internalization, immunoblotting and immunohistochemistry of signaling molecules, in situ hybridization). (A collaboration on high throughput phosphoproteomics is part of the project.) In addition, we will characterize neurons expressing KOR in the claustrum, in terms of their neuronal circuitry, neurotransmitters and functional roles in KOR-mediated behaviors. A recently generated knockin mouse strain expressing a fusion protein of KOR conjugated with a fluorescent protein will be used in these studies. Characterization of wildtype and mutant mouse lines with conditional deletion of the KOR or expressing mutant KORs and injection of viral constructs into brain regions are among the approaches to be used.
Stipend, medical insurance coverage, and travel funds are supported by NIH Institutional Training Awards. The initial appointment will be for one year with the possibility of renewal for 2 more yrs.
Temple University is an EEO/AA employer and strongly encourages applications from women and minorities.
A recent Ph.D. degree (within the past two years) in neuroscience, pharmacology or an equivalent and US citizenship or permanent residency are required. Candidates with experience in some of the above techniques and good written and oral communication skills are preferred. The ability to work independently in a supportive and interactive environment is strongly desirable Please send a cover letter, curriculum vitae and names of three references to Lee-Yuan Liu-Chen, Ph.D., e-mail: firstname.lastname@example.org, or Center for Substance Abuse Research, Temple University School of Medicine, 3500 North Broad Street, MERB851, Philadelphia, PA 19140.