This position will be funded by an NIMH R01 grant. It will examine the vulnerability of DHCR7 /- mutation carriers to aripiprazole, trazodone and other treatments and test the hypothesis that DHCR7/- carriers will show increased vulnerability to ARI and TRZ exposure. More specifically, the project will establish the psychotropic compound-induced biochemical and gene expression disturbances on cultured fibroblasts from DHCR7+/- human carriers. Furthermore, transgenic mouse studies will determine the early and late biochemical, gene expression and behavioral consequences of ARI and TRZ-exposure on the Dhcr7+/- heterozygous transgenic mice. The hired candidate will be responsible for all biochemical/chemical aspects of this, and future projects.
Individuals from diverse backgrounds are encouraged to apply. Applications should include a cover letter, CV, description of research accomplishments and the names and contact information of three individuals who can provide letters of reference. All applications must be submitted on-line at https://unmc.peopleadmin.com/postings/35284.
PhD and successfully completed postdoctoral fellowship in biochemistry or chemistry, with strong background in GC-MS, LC-MS and related analytical methods. Demonstrated experience with chemical lipid/cholesterol biosynthesis analyses and cell culturing is strongly preferred.
Demonstrated experience with chemical lipid/cholesterol biosynthesis analyses and cell culturing is essential.
Additional Salary Information: Salary Commensurate with Experience
Chancellor: Jeffrey P. Gold, M.D.
Enrollment (Fall 2015): 3,790 students
Employees (October 2014): 4,928 (4,177.6 FTE)
Operating Budget (2014-2015): $689.5 million (20.2 percent state-supported)
Founded: 1881. Originally the Omaha Medical College, the college became affiliated with the University of Nebraska in 1902.
Major Units: College of Medicine, College of Nursing, College of ...Pharmacy, College of Dentistry, College of Public Health, Graduate College, College of Allied Health Professions, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, Munroe-Meyer Institute, Stanley M. Truhlsen Eye Institute.
University of Nebraska: The University of Nebraska Medical Center is one of four campuses of the University of Nebraska. The others are: the University of Nebraska-Lincoln (UNL), the University of Nebraska at Omaha (UNO) and the University of Nebraska at Kearney (UNK).
Economic Impact: UNMC and its hospital partner, Nebraska Medicine, have an annual impact of $4.2 billion.
In the most recent ranking of graduate schools by U.S. News & World Report, UNMC primary care program ranked fourth of 153 medical schools, and its physician assistant program ranked ninth. Its physical therapy, pharmacy and public health programs also are ranked among the best in the country.
Nearly half of Nebraska’s physicians, dental professionals, pharmacists, bachelor-prepared nurses and allied health professionals have graduated from UNMC.
UNMC is the professional and scientific home of determined, brilliant researchers who work at the forefront of fields such as transplant medicine, cancer, neurodevelopment and genomics.
With collaboration from a highly engaged community of skilled professionals and access to world-class facilities, UNMC researchers identify and focus on critical questions that lead to new knowledge and, in the long term, life-changing therapies. Breakthroughs like stem cell transplantation to treat cancer have proven critical to Nebraska, the nation and the world. http://www.unmc.edu/research