The Center for Dementia Research at the Nathan S. Kline Institute (NKI) consists of a consortium of investigators who are dedicated to studies on the pathogenesis, diagnosis, and treatment of Alzheimer’s disease (AD) and other major neurodegenerative diseases. The institute is in Orangeburg, NY close to New York City, and provides a unique research and training opportunity combining molecular, morphologic, and in vitro and in vivo approaches in a multidisciplinary setting. The NKI is affiliated with New York University School of Medicine, and a shuttle runs daily between NYU and the NKI. Please visit Dr. Levy's Lab website listed below for information on her lab members, research and publications:
Two newly NIA-funded postdoctoral positions for recent Ph.D. are available immediately in the laboratory of Dr. Levy at the NKI.
The first position focuses on the anti-amyloidogenic and neuroprotective properties of a novel, naturally occurring mutation in the amyloid beta peptide found in an Italian family. This post-doctoral fellow will investigate whether the interaction between the Italian amyloid beta, which contains an amino acid substitution at residue 2 of amyloid beta, and wild-type amyloid beta hinders amyloid beta oligomerization, amyloidogenesis and neurotoxicity using unique transgenic mouse models. Overall, these studies will address multiple mechanisms by which Italian amyloid beta appears to be protective. Additionally, this applicant will use exosomes as vehicles to deliver protective Italian amyloid beta within the brain, a novel therapeutic approach for Alzheimer’s disease.
A second research position is part of a collaborative undertaking including Drs. Paul M. Mathews and Donald A. Wilson, also at the NKI and NYU School of Medicine, investigating cell biological responses to different apolipoprotein E alleles that either protect from or predispose neurons to neurodegenerative risk both early in AD as well as independently of hallmark AD pathology. Our studies examine vesicular trafficking and functional differences in the endosomal and exosomal systems mediated by apolipoprotein E. Experimental models include human brain tissue, mouse models, and in vitro culture systems. Therapeutic strategies building upon the protective effects of apolipoprotein E2 are one of the long-term goals of this project.
These studies routinely employ multidisciplinary approaches including behavioral tests of mouse models, and electron microscopy, immunolabeling, standard biochemistry, as well as genomic, proteomic and lipidomic approaches of mouse brain tissue, human postmortem brain tissue, and in vitro cultured cells.
The research focus of these positions shares substantial synergy with a recently renewed program project involving Drs. Levy and Mathews and additional laboratories and PIs at the Nathan S. Kline Institute. Joint laboratory meetings, shared resources including mouse colonies, and an overall highly collaborative environment contribute to a strong training environment.
Useful prior experience includes:
rodent husbandry, including familiarity with standard behavioral assessments
cell culture, primary neuronal cultures
tissue and cell immunolabeling for confocal microscopy
PCR, Western blot, subcellular fractionation
In addition to these technical skills, the successful applicant will have a strong record of written productivity, including prior manuscripts and, potentially, fellowship applications. Appropriate grant and fellowship applications will be strongly encouraged.
Applicants must have a recent Ph.D. or the equivalent and a strong research background as evidenced by peer-reviewed publications in international journals.
To apply, please send a full CV, a brief statement of current research and long-term goal, and names and contact information of three references to Dr. Levy at email@example.com. The SFN meeting will offer a potential opportunity for a follow up face-to-face meeting.
The Research Foundation is a private not-for-profit corporation and is not an agency or instrumentality of the State of New York. Employees of the Research Foundation are not state employees, do not participate in any state retirement system, and do not receive state fringe benefits. Excellent Benefits Package. Affirmative Action/Equal Opportunity Employer/Minority/Women/Disabled/Veteran Employer.... VEVRAA 41 CFR 60-300.5(a) compliant.
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