Postdoctoral positions (1-2) are available for a motivated, ambitious, and talented scientist interested in learning and studying cellular neurophysiology, synaptic function, and synaptic plasticity of: 1) brainstem circuits in the context of feeding and metabolic regulation; or 2) hippocampal circuits after brain injury. Learn/contribute to studies in rodents using multidisciplinary approaches, including in vitro electrophysiology, optogenetic/chemogenetic brain circuit modulation, molecular biology, immunochemistry, cell biology, and behavioral analyses.
Preference will be given to applicants who recently received their PhD degree or graduated within 3 years and/or have demonstrable experience with patch-clamp recordings in brain slices. Must enjoy working in a friendly and collaborative lab environment and appreciate collaborative and supportive scientific interactions. Competitive salary, commensurate with experience. Equal opportunity employer.
Bret N Smith is Professor of Physiology and Neuroscience and Interim Chair, Department of Neuroscience at the University of Kentucky College of Medicine. Research in this laboratory is aimed at understanding the mechanisms underlying functional synaptic connectivity, modulation, and plasticity of neuronal systems. Using whole-cell electrophysiological techniques in acute slice preparations combine...d with molecular, immunochemical, histochemical, biochemical, behavioral, optogenetic/chemogenetic, and neuropharmacological methods, we are conducting studies to determine how synaptic function in central autonomic control areas regulates visceral sensory-motor integration as well as how neural circuit organization and remodeling contribute to development of epilepsy. The specific areas of study are:
1. Synaptic organization of neurons regulating autonomic function - Synaptic plasticity of brain systems controlling visceral/autonomic functions in metabolic disorders.
2. Synaptic reorganization in the epileptic brain -Synaptic reorganization and modulation in temporal lobe epilepsy and posttraumatic epilepsy.