Position available immediately in the Department of Anatomy & Neurobiology at the University of Maryland, Baltimore. Successful candidate will be stationed in the laboratory of Reha Erzurumlu and will work on joint projects with Daniel O’Connor at the Department of Neurosciences, the Johns Hopkins University Medical School. Applicants must have demonstrated experience in one or more of the following: in vivo and in vitro electrophysiology, optogenetics, axonal/cellular tracing and imaging techniques. Available projects are on the development and plasticity of the mouse whisker-barrel system in wild type and transgenic animals (see recent papers from the Erzurumlu and O’Connor laboratories listed on Pubmed.) A strong background in electrophysiology, molecular biology, and fluorescence imaging techniques is required; mouse behavioral testing experience highly desirable. Interested candidates should submit statement of research interest, current CV and names of 3 references by e-mail: email@example.com
A strong background in electrophysiology, molecular biology, and fluorescence imaging techniques is required; mouse behavioral testing experience highly desirable.
Erzurumlu lab: "Cellular and molecular mechanisms underlying axon-target interactions in mammalian sensory pathways. Molecular mechanisms of sensory axon elongation and arborization. Activity-dependent refinement of synaptic connections. NMDA receptor-mediated development and patterning of sensory maps. Recent research focuses on the development and plasticity of the cerebral cortex and somatosens...ory pathways. We use molecular biology, in vitro and in vivo electrophysiology, imaging, neuroanatomy and behavioral techniques to understand mechanisms underlying development of topographic maps, neural patterning, plasticity and neonatal injury-induced alterations in the trigeminal system."
O'Connor Lab: "How do brain dynamics give rise to our sensory experience of the world? We work to answer this question by taking advantage of the fact that key architectural features of the mammalian brain are similar across species. This allows us to leverage the power of mouse genetics to help monitor and manipulate genetically and functionally defined brain circuits during perception. We train mice to perform simple perceptual tasks. By using quantitative behavior, optogenetic and chemical-genetic gain- and loss-of-function perturbations, in vivo two-photon imaging, and electrophysiology, we assemble a description of the relationship between neural circuit function and perception. We work in the mouse tactile system to capitalize on an accessible mammalian circuit with a precise mapping between the sensory periphery and multiple brain areas."