The Scherrer lab at Stanford University is accepting applications from outstanding individuals for several open postdoctoral positions. Successful candidates will be investigating the neural circuits and molecular mechanisms underlying pain and its control by opioids, using a variety of techniques including cellular and molecular biology, mouse genetics, transcriptomics, neuroanatomy, electrophysiology, optogenetics, in vivo calcium imaging, and behavior. A strong background in the pain and opioid fields and/or expertise in the above mentioned techniques is necessary. In particular, we are looking for talented molecular neuroscientists with experience with single cell RNA sequencing, electrophysiologists with experience with whole-cell recordings in spinal cord/brain slices or in vivo primary afferent intracellular recordings, and pain behavioral pharmacologists. The Scherrer laboratory is part of the Stanford Neuroscience Institute and Anesthesiology, Molecular and Cellular Physiology, and Neurosurgery departments, providing a dynamic research environment and exceptional resources for training in the pain and opioid fields.
The following articles illustrate our approach to pain and opioid research:
Corder G, Tawfik VL, Wang D, Sypek EI, Low SA, Dickinson JR, Sotoudeh C, Clark DJ, Barres BA, Bohlen C, Scherrer G. Loss of mu opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesia. Nature Medicine. 2017 Feb 23. PMID: 28092666.
François A, Low SA, Sypek E, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Sharif-Naeini R, Deisseroth K, Scott L Delp, Malenka R, Luo L, Hantman A, Scherrer G. A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins. Neuron. 2017 Jan 31. PMID: 28162807.
Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 Aug 17. PMID: 27533032.
Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Cassidy C, Smith C, de Nooij JC, Mennicken F, O’Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron. 2014 Mar 19. PMCID: PMC4072501.
Please contact Gregory Scherrer, email@example.com with your previous experience and motivation for such a position.