An outstanding and highly-motivated post-doctoral fellow is sought to participate in translational research on intraventricular hemorrhage of premature infants. The ideal candidate should have fewer than five years of postdoctoral experience and a strong publication record in the field of developmental neurobiology/neuroscience.
Our lab is focused on understanding the pathogenesis of intraventricular hemorrhage (IVH) in preterm infants and developing strategies to minimize brain injury in the survivors of IVH. Ongoing interests include evaluating glutamatergic and GABAergic neurogenesis in preterm infants with IVH and employing genetic and pharmacological approach to restore production of cortical neurons and interneurons and neurological function in premature rabbits with IVH. In addition, we are studying the effect of prematurity on dendritic development in rabbit model. The lab also uses autopsy samples from premature infants with and without IVH.
Support: Postdoctoral fellow will be well supported with state-of-the-art equipment dedicated to their experiments. Salary is competitive and commensurate with experience and contribution.
Please contact firstname.lastname@example.org with inquiries and applications. Send statement of interest, CV, and the names of three people for letters of recommendation. Position is available immediately.
postdoctoral fellowship: less than 5 yearsS
Additional Salary Information: Salary is competitive and commensurate with experience and contribution.
Our laboratory studies the pathogenesis of intraventricular hemorrhage (IVH) and evaluates neuro-protective strategies to prevent brain injury after IVH in premature infants. The major projects in our laboratory are focused on determining a) the mechanisms underlying white matter injury in premature infants with IVH and approaches to minimize the damage, b) the effect of IVH on glutamatergic neur...ogenesis and corticogenesis in the developing brain, and strategies to restore these processes, and c) the effect of prematurity on neurogenesis and corticogenesis.
To answer our research questions, we employ a preterm rabbit model (in vivo studies) and an in vitro organotypic forebrain slice culture model of IVH. Our glycerol model of IVH in preterm rabbits exhibits periventricular white matter injury and post-hemorrhagic hydrocephalus similar to that seen in human preterm survivors with IVH. In addition, we analyze autopsy samples from preterm infants with and without IVH. Commonly used techniques include Immunohistochemistry, confocal microscopy, stereological quantification of neural cells, Western blot analyses, real time qPCR, slice culture, neuronal migration studies, viral gene transfer, flow-cytometry, and magnetic bead isolation of cells.