A position is available for a molecular and cellular neurobiologist interested in investigating how the Neuregulin (NRG)\ErbB4 signaling pathway, which is genetically associated with an increased risk for schizophrenia and bipolar disorder, regulates neuronal differentiation and synaptic properties in the brain.
Our recent studies discovered that, depending on protein secondary structure, distinct members of the NRG family are trafficked differentially to either neuronal soma or axons. Unprocessed single-transmembrane proNRG isoforms are targeted to soma and accumulate atop of subsurface cisternae (specialized extensions of endoplasmic reticulum), where they are processed and released in an activity-dependent fashion. By contrast, dual-transmembrane NRGs are processed by BACE1 in the Golgi and trafficked to axons. Our goal is to understand the mechanisms that govern NRG processing and their differential functions that ultimately contribute to altered behaviors associated with cognition (see Nat Comm 2015 (PMID 26027736), Mol Psych 2017 (PMID 28322273), J Neurosci 2017 (PMID 28432142)).
Please send applications including a curriculum vitae, a statement of research interests and long-term career goals, and the name, email and mailing addresses of three references by August 31, 2017 to: Dr. Andres Buonanno, Section on Molecular Neurobiology, Porter Neuroscience Research Center, Building 35 Rm 2C-1000, Bethesda, MD 20892. (firstname.lastname@example.org).
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molecular and cellular neurobiologist interested in investigating how the Neuregulin (NRG)\ErbB4 signaling pathway regulates neuronal differentiation and synaptic properties in the brain.
Additional Salary Information: between 44-48,000 + benefits